Here is a poster presented at SBI2 in collaboration with: Mayo Clinic. This poster reveals how NucleoLIVE™, our non-toxic biocompatible nuclear probe, is designed to study long-term changes of cell populations. It addresses the limitations of current nuclear staining methods, such as time-consuming lentiviral transfection and the toxicity of existing dyes in long-term assays.

NucleoLIVE™ excels in enabling extended monitoring of cell proliferation and viability , with primary validation demonstrating no impact on cell proliferation over 6 days. As a "mix-and-read" reagent, it simplifies automation workflows and offers excellent compatibility for multiplexing with other live cell fluorophores.

This probe is ideal for cell segmentation in bio-image analysis , supporting real-time cell segmentation in kinetic assays due to its biocompatibility and high signal-to-noise ratio. NucleoLIVE™ represents a significant advancement in drug discovery and cell biology tools , providing a new level of detail for understanding drug effects and disease biology through real-time cell counting and long-term proliferation assays.