Broad Institute: comparing ChromaLIVE™ vs Cell painting. SBI2 2023 Poster.

Broad Institute: comparing ChromaLIVE™ vs Cell painting. SBI2 2023 Poster.

 

Explore this poster presented at SBI2 by the Broad Institute of MIT and Harvard, a project where Saguaro Biosciences contributed the dyes and guidance for their use. This study focuses on the "Evaluation of the performance of various cell dyes for Cell Painting assay".

It investigates new dye products, including Saguaro ChromaLive, designed to observe live cell dynamics over time or augment traditional Cell Painting dye sets. It highlights that all tested dye sets, including ChromaLIVE, allow for good replicate identification for image-based profiling.

Notably, live cell dyes designed for live-cell imaging demonstrate a distinct performance profile across various mechanisms of action compared to standard fixed Cell Painting dyes, offering complementary insights into cellular responses.