From Genes to Images: the Unexpected Power of Cell Images to Decode Drug Mechanism

From Genes to Images: the Unexpected Power of Cell Images to Decode Drug Mechanism

Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...
5 Reasons Why Drug Discovery Leaders Choose Live Cells for their Cell Painting Assay

5 Reasons Why Drug Discovery Leaders Choose Live Cells for their Cell Painting Assay

Context Multiple drug discovery and academic groups have adopted image-based profiling in the last decade for many good reasons: akin to other profiling methods like transcriptomics or proteomics, it captures rich biological data that’s overlapping and...
Protocol - NucleoLIVE™ non-toxic nuclear dye

Protocol - NucleoLIVE™ non-toxic nuclear dye

Optimize your live-cell imaging studies with NucleoLIVE™, our non-toxic nuclear dye. Live-cell nuclear labeling is crucial to cell biology research for precise measurements of cell count, proliferation or image segmentation. Our non-toxic nuclear dye finally...
Protocol - ChromaLIVE™ non-toxic dye

Protocol - ChromaLIVE™ non-toxic dye

ChromaLIVE™ is the ideal non-toxic dye and leading technology for image-based profiling. Instead of using multiple dyes and having to fix cells as in cell painting, ChromaLIVE relies on live-cell imaging to evaluate cells in...
Protocol - ChromaLIVE™ Deep Red non-toxic dye

Protocol - ChromaLIVE™ Deep Red non-toxic dye

Explore ChromaLIVE™ Deep Red, the same as our original ChromaLIVE, but with different spectral properties, allowing compatibility with NucleoLIVE non-toxic nuclear dye.  Learn its simple protocol, instrument compatibility and how to optimize your cell imaging...
Protocol - MortaLIVE™ non-toxic dye

Protocol - MortaLIVE™ non-toxic dye

Optimize your live-cell assay and cytotoxicity assay assessment with MortaLIVE™, one of Saguaro Biosciences' non-toxic dyes. MortaLIVE™ is a non-toxic cell viability dye that enables real-time monitoring of cytotoxicity, crucial for high-content imaging and real-time...
Purchase Terms And Conditions

Purchase Terms And Conditions

 
ChromaLIVE Deep Red and NucleoLIVE Red for Live Cell Painting and Phenotypic Profiling

ChromaLIVE Deep Red and NucleoLIVE Red for Live Cell Painting and Phenotypic Profiling

Explore this technical note introducing ChromaLIVE™ Deep Red, a novel non-toxic dye optimized for compatibility with NucleoLIVE™ Red. This new variation of our signature ChromaLIVE™ stain addresses limitations in traditional endpoint high-content screening and cell...
Application Note - MortaLIVE™ non-toxic dye: live-dead assay for real-time cytotoxicity

Application Note - MortaLIVE™ non-toxic dye: live-dead assay for real-time cytotoxicity

Cell viability and cell death assays are essential tools to evaluate compound cytotoxicity in drug discovery. While many commercial solutions exist, most are endpoint assays that only capture a snapshot at a single timepoint. MortaLIVE™...
How does ChromaLIVE™ non-toxic dye work?

How does ChromaLIVE™ non-toxic dye work?

ChromaLIVE™ is a non-toxic live-cell dye that operates through a unique molecular rotor mechanism. It enables high-content phenotypic profiling without perturbing cells. Instead of binding to specific biomarkers like traditional stains, ChromaLIVE passively incorporates into...

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