In this how-to-guide, we report the design of a new high-throughput screening (HTS) workflow for non-toxic live cell painting, which allows scientists to capture new profiling data at scale, with toolsthat preserve cell physiology. Our...

  Accelerate your adoption of 3D organoids as a New Approach Methodology. This reference details how to deliver comprehensive insights through standardized, tailor-made assays. Discover our non-toxic, live-cell imaging approach using NucleoLIVE™ and MortaLIVE™ to enable...

   

ChromaLIVE™ is a non-toxic live-cell dye that operates through a unique molecular rotor mechanism. It enables high-content phenotypic profiling without perturbing cells. Instead of binding to specific biomarkers like traditional stains, ChromaLIVE passively incorporates into...

  This reference guide outlines the Key Considerations for Live Cell Painting (LCP) screens applied to High-Throughput Screening (HTS). LCP offers superior biological relevance by capturing cells in their most physiological, unperturbed state, compared to...

Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...