This reference guide outlines the Key Considerations for Live Cell Painting (LCP) screens applied to High-Throughput Screening (HTS). LCP offers superior biological relevance by capturing cells in their most physiological, unperturbed state, compared to...

Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...

Context Multiple drug discovery and academic groups have adopted image-based profiling in the last decade for many good reasons: akin to other profiling methods like transcriptomics or proteomics, it captures rich biological data that’s overlapping and...

Discover new insights into Immune Cell Killing (ICK) assays with this application note that describes a novel application for ChromaLIVE™, a non-toxic dye used in live-cell imaging to provide continuous and quantitative monitoring of effector-target...

Unlock new compound insights in long-term live-cell assays by combining ChromaLIVE™ Non-Toxic Dye with The Incucyte® Live-Cell Analysis System. This application note, developed in collaboration with Sartorius, guides users on leveraging these two live-cell technologies...

Explore our collaboration with Merck! Our poster, "Morphological Profiling: Comparing Cell Painting and Live Cell Painting for Deconvoluting Cellular Toxicity Kinetics and Types of Cell Death Mechanisms in High-Throughput", showcases ChromaLIVE™. This study, utilizing Merck's...

This poster, a collaboration with Yokogawa and SUN Bioscience, showcases an innovative workflow for kinetic morphological profiling of live 3D spheroid models. Learn how ChromaLIVE™ Live Cell Painting assay provides non-toxic staining of live cells...

This poster, in collaboration with NTNU and Mayo Clinic, reveals how NucleoLIVE™, our non-toxic nuclear dye, revolutionizes long-term live imaging of 2D and 3D cell cultures. NucleoLIVE™ effectively overcomes the limitations of existing nuclear dyes...

Discover how ChromaLIVE™ redefines Live Cell Painting with unsurpassed performance for phenotypic profiling. This technical note showcases ChromaLIVE™ as a non-toxic dye that excels in live-cell imaging, boosting bioactive compound detection and minimizing false predictions...

An Exploration Of Time-Dependent Phenotypic Changes For Enhanced Drug Discovery