In this how-to-guide, we report the design of a new high-throughput screening (HTS) workflow for non-toxic live cell painting, which allows scientists to capture new profiling data at scale, with toolsthat preserve cell physiology. Our...

  ChromaLIVE+ ER is the latest and highest performing Cell Painting technology that pushes the boundaries of image-based profiling. Building on our ChromaLIVE technology and our endoplasmic reticulum dye ER-LIVE, this powerful, non-toxic dye combination...

ChromaLIVE™ is the ideal non-toxic dye and leading technology for image-based profiling. Instead of using multiple dyes and having to fix cells as in cell painting, ChromaLIVE relies on live-cell imaging to evaluate cells in...

Explore ChromaLIVE™ Deep Red, the same as our original ChromaLIVE, but with different spectral properties, allowing compatibility with NucleoLIVE non-toxic nuclear dye.  Learn its simple protocol, instrument compatibility and how to optimize your cell imaging...

ChromaLIVE™ is a non-toxic live-cell dye that operates through a unique molecular rotor mechanism. It enables high-content phenotypic profiling without perturbing cells. Instead of binding to specific biomarkers like traditional stains, ChromaLIVE passively incorporates into...

  This reference guide outlines the Key Considerations for Live Cell Painting (LCP) screens applied to High-Throughput Screening (HTS). LCP offers superior biological relevance by capturing cells in their most physiological, unperturbed state, compared to...

Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...

Context Multiple drug discovery and academic groups have adopted image-based profiling in the last decade for many good reasons: akin to other profiling methods like transcriptomics or proteomics, it captures rich biological data that’s overlapping and...