Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...

Context Multiple drug discovery and academic groups have adopted image-based profiling in the last decade for many good reasons: akin to other profiling methods like transcriptomics or proteomics, it captures rich biological data that’s overlapping and...

ChromaLIVE™ is the ideal non-toxic dye and leading technology for image-based profiling. Instead of using multiple dyes and having to fix cells as in cell painting, ChromaLIVE relies on live-cell imaging to evaluate cells in...

Explore ChromaLIVE™ Deep Red, the same as our original ChromaLIVE, but with different spectral properties, allowing compatibility with NucleoLIVE non-toxic nuclear dye.  Learn its simple protocol, instrument compatibility and how to optimize your cell imaging...

Explore this technical note introducing ChromaLIVE™ Deep Red, a novel non-toxic dye optimized for compatibility with NucleoLIVE™ Red. This new variation of our signature ChromaLIVE™ stain addresses limitations in traditional endpoint high-content screening and cell...

ChromaLIVE™ is a non-toxic live-cell dye that operates through a unique molecular rotor mechanism. It enables high-content phenotypic profiling without perturbing cells. Instead of binding to specific biomarkers like traditional stains, ChromaLIVE passively incorporates into...

Discover new insights into Immune Cell Killing (ICK) assays with this application note that describes a novel application for ChromaLIVE™, a non-toxic dye used in live-cell imaging to provide continuous and quantitative monitoring of effector-target...

Unlock new compound insights in long-term live-cell assays by combining ChromaLIVE™ Non-Toxic Dye with The Incucyte® Live-Cell Analysis System. This application note, developed in collaboration with Sartorius, guides users on leveraging these two live-cell technologies...

Explore our collaboration with Merck! Our poster, "Morphological Profiling: Comparing Cell Painting and Live Cell Painting for Deconvoluting Cellular Toxicity Kinetics and Types of Cell Death Mechanisms in High-Throughput", showcases ChromaLIVE™. This study, utilizing Merck's...

This poster, a collaboration with Yokogawa and SUN Bioscience, showcases an innovative workflow for kinetic morphological profiling of live 3D spheroid models. Learn how ChromaLIVE™ Live Cell Painting assay provides non-toxic staining of live cells...