ChromaLIVE™ is a non-toxic live-cell dye that operates through a unique molecular rotor mechanism. It enables high-content phenotypic profiling without perturbing cells. Instead of binding to specific biomarkers like traditional stains, ChromaLIVE passively incorporates into...

  This reference guide outlines the Key Considerations for Live Cell Painting (LCP) screens applied to High-Throughput Screening (HTS). LCP offers superior biological relevance by capturing cells in their most physiological, unperturbed state, compared to...

Introduction The search for new medicines has long been dominated by two main strategies: target-based and phenotypic screening. While target-based approaches focus on a single, well-understood biomarker, phenotypic screening takes a broader view, testing drugs...

Context Multiple drug discovery and academic groups have adopted image-based profiling in the last decade for many good reasons: akin to other profiling methods like transcriptomics or proteomics, it captures rich biological data that’s overlapping and...

Explore this technical note introducing ChromaLIVE™ Deep Red, a novel non-toxic dye optimized for compatibility with NucleoLIVE™ Red. This new variation of our signature ChromaLIVE™ stain addresses limitations in traditional endpoint high-content screening and cell...

Cell viability and cell death assays are essential tools to evaluate compound cytotoxicity in drug discovery. While many commercial solutions exist, most are endpoint assays that only capture a snapshot at a single timepoint. MortaLIVE™...

Discover new insights into Immune Cell Killing (ICK) assays with this application note that describes a novel application for ChromaLIVE™, a non-toxic dye used in live-cell imaging to provide continuous and quantitative monitoring of effector-target...

Unlock new compound insights in long-term live-cell assays by combining ChromaLIVE™ Non-Toxic Dye with The Incucyte® Live-Cell Analysis System. This application note, developed in collaboration with Sartorius, guides users on leveraging these two live-cell technologies...

Explore our collaboration with Merck! Our poster, "Morphological Profiling: Comparing Cell Painting and Live Cell Painting for Deconvoluting Cellular Toxicity Kinetics and Types of Cell Death Mechanisms in High-Throughput", showcases ChromaLIVE™. This study, utilizing Merck's...